ADVANCED INTERMEDIATES AND KEY STARTING MATERIALS
BHAVANISH LIFESCIENCES
ADVANCED INTERMEDIATES AND KEY STARTING MATERIALS
Bhvanish Lifesciences operates multiple large intermediate manufacturing plants capable of handling complex reactions and can manufacture according to customer requirements
| Sr.No | PRODUCT NAME | Details |
| 1 | Benserazide Hydrochloride |
Indication: Parkinson's disease Intermediate 1: 2,3,4-Trihydroxy benzaldehyde * CAS Number: [2144-08-3] Intermediate 2: DL-Serine hydrazide hydrochloride * CAS Number: [55819-71-1] |
| 2 | Eluxadoline |
Indication: Irritable bowel syndrome with diarrhea Intermediate 1: (S)-1-(4-phenyl-1h-imidazol-2-yl) ethanamine * CAS Number: [864825-23-0] Intermediate 2: 5-formyl-2-methoxy-benzoic acid methyl ester * CAS Number: [78515-16-9] Intermediate 3: Phenacyl chloride (or 2-chloroacetophenone) * CAS Number: [532-27-4] |
| 3 | Celecoxib |
Indication: Anti-inflammatory drug Intermediate 1: 4-Hydrozino benzene sulphonamide hydrochloride (HBSH) * CAS Number: [17852-52-7] Intermediate 2: 4,4,4-trifluoro-1-(4-methylphenyl) butane-1,3-dione (Celecoxib TFMB intermediate) * CAS Number: [720-94-5] |
| 4 | Irbesartan |
Indication: Hypertension Intermediate 1: 2-cyano-4-bromo methyl biphenyl (CBMB) * CAS Number: [114772-54-2] |
| 5 | Penciclovir |
Intermediate Name: 6-chloro-9h-purin-2-amine (Penciclovir intermediate) * CAS Number: [10310-21-1] * Details: Used for various herpes simplex virus (HSV) infections. |
| 6 | Mirtazapine |
Intermediate Name: 1-(3-cyanopyridyl-2)-2-phenyl-4-methylpiperazine * CAS Number: [61337-88-0] * Details: Antidepressant Intermediate Name: 1-(3-carboxy pyridyl-2)-2-phenyl-4-methylpiperazine * CAS Number: [61338-13-4] Intermediate Name: 1-(3-hydroxymethylpyridyl-2)-2-phenyl-methylpiperazine * CAS Number: [61337-89-1] |
| 7 | Candesartan |
Intermediate Name: (±)-cyclohexyl-1-chloroethyl carbonate (Cilexetil chloride) * CAS Number: [99464-83-2] * Details: Used for hypertension. |
| 8 | Ribavirin |
Intermediate Name: 1-(2,3,5-tri-o-acetyl-β-d-ribifuranosyl)-1h-1,2,4-triazole-3-carboxylic acid, methyl ester * CAS Number: [39925-10-5] * Details: Antiviral. |
| 9 | Risperidone |
Intermediate Name: 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (Risperidone isoxazole intermediate) * CAS Number: [84163-13-3] * Details: Antipsychotic. |
| 10 | Bupropion HCL |
Intermediate: 3-Chloropropiophenone * CAS Number: [34841-35-5] Details: Antidepressant |
| 11 | Carvedilol |
Intermediate: 4-Hydroxycarbazole * CAS Number: [52602-39-8] * Details: Hypertension |
| 12 | Paracetamol |
Intermediate: 4-Amino phenol development (KSM paracetamol) * CAS Number: [123-30-8] * Details: Analgesic |
| 13 | Brivaracetam |
Intermediate: (R)-4-propyldihydrofuran-2(3H)-one * CAS Number: [63095-51-2] * Details: Anticonvulsant |
| 14 | Aripiprazole |
Intermediate: 7-(4-bromobutoxy)-3,4-dihydrocarbostyril * CAS Number: [129722-34-5] * Details: Antipsychotic |
| 15 | Sildenafil Citrate |
Intermediate: 1-Methyl-3n-propyl-1H pyrazole-5-carboxylic acid * CAS Number: [139755-99-0] * Details: Viagra, used to treat erectile dysfunction (impotence) Intermediate: 1-Methyl-4-nitro-3-propyl pyrazoic acid * CAS Number: [139756-00-6] |
| 16 | Telmisartan |
Intermediate: 2-(4'methylphenyl) benzoic acid biphenylacid * CAS Number: [7148-03-0] * Details: Hypertension Intermediate: Methyl-2-(4'-(bromomethyl-phenyl)) benzoate bromobiphenyl methyl ester * CAS Number: [114772-38-2] |
| 17 | Pioglitazone |
Intermediate: 2-(5-ethylpyridine-2yl)ethyl methyl sulfonate * CAS Number: [144809-26-7] * Details: Type 2 diabetes Intermediate: 4-(2-(5-ethylpyridine-2yl) ethoxy) benzaldehyde (pioaldehyde) * CAS Number: [114393-97-4] Intermediate: 5-[4-[2-(5-ethyl-2-pyridyl) ethoxy] benzylidene]-2,4-thiazolidinedione * CAS Number: [627502-58-3] |
| 18 | Escitalopram Oxalate |
Intermediate: (±)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile (citalopram diol) * CAS Number: [103146-25-4] * Details: Anxiety disorders Intermediate: (±)-4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxy butyl)-3-(hydroxymethyl)benzonitrile oxalate (citalopram diol) * CAS Number: [717133-32-9] |
| 19 | Losartan Potassium |
Intermediate: 2-n-butyl-4-chloro-5-formyl imidazole (BCFI) * CAS Number: [83857-96-9] * Indication: Hypertension |
| 20 | Guanine |
Intermediate: 2-Aminohypoxanthine, 2-Amino-6-hydroxypurine, 2-Amino-1,7-dihydro-6H-purin-6-one * CAS Number: [73-40-5] * Indication: KSM |
| 21 | Olmesartan Medoxomil |
Intermediate 1: Diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate Intermediate 2: Trityl Olmesartan diester * CAS Number: [144689-94-1] * Indication: Hypertension |
| 22 | Perindopril |
Intermediate: Tert-butylamine * CAS Number: [107133-63-8] * Indication: Hypertension |
| 23 | Terbinafine HCL |
Intermediate: (2E and 2Z)-1-chloro-6,6-dimethyl 2-hepten-4-yne * CAS Number: [126764-17-8] * Indication: Antifungal Intermediate: 6,6-dimethylhept-1-en-4yn-3-ol * CAS Number: [78629-20-6] |
| 24 | Tetrazosin Base |
Intermediate: 1-(4-amino-6,7-dimethoxyquinazolin-2xl)-4-[[2rs)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine * CAS Number: [63590-64-7] * Indication: Adrenergic alpha-1 antagonist |
| 25 | Telmisartan |
Intermediate 1: Bromobiphenyl methylester Intermediate 2: Methyl-2-[4'-(bromomethylphenyl)benzote] Intermediate 3: 4'[[4-methyl-6-(1-methyl-1h-benzimidazol-2-yl)-2-propyl-1h-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid, methyl ester Intermediate 4: 2-(4'-methylphenyl) benzoic acid * CAS Number: [528560-93-2] * Indication: Hypertension |
| 26 | Risperidone |
Intermediate: 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4h-pyrido[1,2-a]pyrimidan-4-one hydrochloride [Risperidone piperidopyrimidinone] * Category: Antipsychotic * CAS Number: [93076-03-0] |
| 27 | Ribavirin |
Intermediate: 1-(2,3,5-tri-o-acetyl-β-d-ribofuranosyl)-1h-1,2,4-triazole-3-carboxylic acid methyl ester * Category: Antiviral * CAS Number: [39925-10-5] |
| 28 | Rabeprazole Sodium |
Intermediate: 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyrine hydrochloride (Rabeprazole chloro compound) * CAS Number: [168167-42-8] Intermediate 1: 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1h-benzamidazole (Rabeprazole sulfide) * CAS Number: [117977-89-3] Intermediate 2: (±)2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1h-benzamidazole (Rabeprazole) * CAS Number: [117976-89-3] * Category: Gastrointestinal |
| 29 | Paroxetine hydrochloride |
Indication: Depression Intermediate 1: (-) -(3S,4R)-4-(4-FLUOROPHENYL)-3-MESYLOXYMETHYL-N-METHYLPIPERIDINE (PAROXETINE MESYLATE) * CAS: [608521-21-7] Intermediate 2: (-)-(3S,4R)-4-(4-Fluorophenyl)-3-[[(3,4-Methylenedioxy)phenoxy]methyl]-N-methylpiperidine (N-Methylparoxetine) * CAS: [110429-36-2] Intermediate 3: (-)-(3S,4R)-4-(4-FLUOROPHENYL)-3-[[(3,4-METHYLENEDIOXY)PHENOXY]METHYL]-N-PHENOXYCARBONYLPIPERIDINE (PAROXETINE CARBAMATE) * CAS: [253768-88-6] |
| 30 | Pantoprazole sodium |
Indication: Gastrointestinal Intermediate: 5-difluoromethoxy-2-[[3,4-dimethoxy-2-pyridinyl)methyl]thio]-1h-benzimidazole (Pantoprazole sulfide) * CAS: [102625-64-9] Intermediate 1: 5-diflouromethoxy-2-[[3,4- dimethoxy -2-pyridinyl) methyl] sulfinyl]-1h-benzimidazole * CAS: [102625-70-7] |
| 31 | Modafinil |
Indication: Sleep disorders Intermediate 1: Diphenylmethylthiocarboxamidine (or) Diphenylmethylisothioronium bromide (Isothiouronium salt) * CAS: [90280-15-2] Intermediate 2: Diphenylmethanethiol * CAS: [4237-48-3] Intermediate 3: 2-[(Diphenylmethyl)thio]acetic acid * CAS: [63547-22-8] Intermediate 4: 2-[(Diphenylmethyl)thio]acetyl chloride * CAS: [68524-29-8] Intermediate 5: 2-[(Diphenylmethyl)thio]acetamide * CAS: [68524-30-1] |
| 32 | Losartan potassium |
Indication: Hypertension Intermediate: 2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2’(2h-tetrazole -5-yl) biphenyl-4-yl]methyl]imidazole * CAS: [114798-26-4] |
| 33 | Lisinopril dihydrate |
Indication: Hypertension Intermediate 1 : N6-(Trifluoroacetyl)-Lysine * CAS: [10009-20-8] Intermediate 2 : N6-(triflouroacetyl)-n2-carboxy-l-lysine anhydride * CAS: [42267-27-6] Intermediate 3 : N6-(triflouroacetyl)-L-Lysyl-proline * CAS: [103300-89-6] Intermediate 4 : N6-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-n6-(triflouroacetyl)-L-Lysyl-L-proline * CAS: [103300-91-0] |
| 34 | Glyburide |
Indication: Type 2 diabetes Intermediate: 4-[2-(5-chloro-2-methoxybenzamido) ethyl] benzenesulfonamide potassium (Glyburide penultimate potassium) |
| 35 | Gemfibrozil |
Indication: Cholesterol Intermediate 1: Isobutyl isobutyrate * CAS: [97-85-8] Intermediate 2: Isobutyl side chain * CAS: [109232-37-3] Intermediate 3: Gemfibrozil isobutyl ester * CAS: [148105-26-0] |
| 36 | Gabapentin |
Indication: Anticonvulsant Intermediate 1 : 1,1-Cyclohexanediacetic anhydride * CAS: [1010-26-0] Intermediate 2 : 1,1-Cyclohexanediacetic acid, monomethyl ester * CAS: [60142-95-2] Intermediate 3 :1,1-Cyclohexanediacetic acid, monoazide, monomethyl ester * CAS: [--] Intermediate 4 : Methyl1-isocyanatomethyl-1- cyclohexaneacetate * CAS: [66024-97-3] Intermediate 5 :1-aminomethyl-1-cyclohexaneacetic acid hydrochloride * CAS: [60142-95-2] |
| 37 | Fluvastatin Sodium |
Indication: Antiparipratinometic
Intermediate 1: t-butyl]R*,S*-e]-(±)-7-]-3-(4- fluorophenyl)-1-(1-methylethyl)- 1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate (T-butyl-3,5-dihydroxy Fluvastatin) * CAS: [129332-29-2] Intermediate 2: (4S,5R)-2-phenyl-4-(fluoromethyl)-5-[4-(methylsulfonyl)phenyl]-2-oxazoline (Fluoro oxazoline) * CAS: [126428-97-5] Intermediate 3: (1R,2S)-1-[4-(Methylsulfonyl)phenyl]-2-amino-3-fluoro-1-propanol (Fluoro amine) * CAS Number: [76639-93-5] |
| 38 | Famciclovir |
Intermediate: 2-amino-9-(4-hydroxy-3-hydromethyl-but-1-yl) purine Hydrochloride * CAS Number: 246021-75-7 * Use: Antiviral |
| 39 | Doxazosin mesylate |
Intermediate: 1-4(-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2rs)-1,4-benzodioxan-2-yl]-Carbonyl] piperzine * CAS Number: 74191-85-8 * Use: Hypertension |
| 40 | Donepezil Hydrochloride |
Intermediate: 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine (Dehydrodonepezil) * CAS Number: 120014-07-5 |
| 41 | Citalopram hydrobromide |
Use: Antidepressant Intermediate1 : α-[4-bromo-2-(hydromethyl) phenyl]-α-(4-fluorphenyl)-α-(3-dimethylaminopropyl) methanol (Bromo diol intermediate) * CAS Number: --- Intermediate 2: 5-bromo-1-(3-dimethylamino propyl)-1-(4-fluorophenyl)-1,3-dihydro iso-benzofuran * CAS Number: [64169-39-7] Intermediate 3 : 1-(3-dimethylamino propyl)-1-(4-fluorophenyl)-1,3- dihydroiso-benzofuran-5-carbonitrile * CAS Number: 207559-01-1 |
| 42 | Candesartan Cilexetil |
Use: Hypertension Intermediate 1: Methyl 2-ethoxy-1-[[2’-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimedazole-7-carboxylate [Candesartan methyl ester] * CAS Number: 139481-69-9 Intermediate 2 : 2-ethoxy-1-[[2’-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimedazole-7-carboxylic acid [Candesartan acid] * CAS Number: 139481-59-7 Intermediate 3 : 2-ethoxy-1-[[2’-(n-triphenyl-methyltetrazole-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid [Trityl candesartan acid] * CAS Number: 139481-72-4 Intermediate 4 : (±)-1-[[cyclohexyloxy)-carbonyl]oxy]ethyl2-ethoxy- 1-[[2’-(n-triphenyl-methyltetrazole-5-yl)biphenyl-4-yl)methyl]benzimidazole-7 carboxylate [Trityl candesartan cilexetil] * CAS Number: [170791-09-9] |
| 43 | Bupropion hydrochloride |
Use: Antidepressant Intermediate 1 : 1-Chloropropiophenone * CAS Number: [34841-35-5] Intermediate 2 : 1-chloro-2-bromopropiophenone * CAS Number: 34911-51-8 Intermediate 3: Bupropion base * CAS Number: 34911-55-2 |
| 44 | Bisoprolol Fumarate |
Use: Hypertension Intermediate: 2-[4-[[2-(1-methylethoxy) ethoxy] methyl] phenoxy methyl] oxirane (Bisoprolol Epoxide) * CAS Number: 66722-57-4 Intermediate: (+_)-1-(4[[2-(1-methylethoxy) ethoxy] methyl]phenoxy]-3-[(1-methylethyl) amino]-2-propanol * CAS Number: 66722-44-9 |
| 45 | Aripiprazole |
Use: Antipsychotics Intermediate: 7-(4-bromobutoxy)-3,4-dihydracarbostyril * CAS Number: 129722-34-5 |
| 46 | Amiodarone hydrochloride |
Use:Antianginal and class III antiarrhythmic Intermediate: 2-butyl-3-(4-methoxybenzoyl) benzofuran * CAS Number: 83790-87-8 Intermediate: 2-butyl-3-(4-hydroxybenzoyl) benzofuran * CAS Number: [52490-15-0] |
| 47 | 4-(Dimethylamino)butanal Diethyl Acetal | CAS Number: 19718-92-4 |
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