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Methotrexate

Methotrexate Impurities & Reference Standards

Methotrexate is a high-purity active pharmaceutical ingredient (API) used in the formulation and manufacture of pharmaceutical products. Methotrexate is registered under CAS Number 59-05-2. The compound carries the molecular formula C20H22N8O5, corresponding to a molecular weight of 454.4 g/mol. High-purity Methotrexate and its related substances / process impurities are essential for analytical method development, method validation, quality control, and regulatory submissions under ICH, USP, BP, and EP guidelines. Our Methotrexate reference standards are provided with full documentation — Certificate of Analysis (CoA), HPLC chromatographic data, and spectral characterization — to support pharmaceutical R&D and GMP manufacturing.

Associated Impurities

Methotrexate Impurity – A

  • CAS No: 945-24-4
  • Mol. F.: C7H8N6O

Methotrexate Impurity – B

  • CAS No: 54-62-6
  • Mol. F.: C19H20N8O5

Methotrexate Impurity – C

  • CAS No: 2410-93-7
  • Mol. F.: C20H21N7O6

Methotrexate Impurity – D

  • CAS No: 5623-18-7
  • Mol. F.: C15H14N6O3

Methotrexate Impurity – E

  • CAS No: 19741-14-1
  • Mol. F.: C15H15N7O2

Methotrexate Impurity – F

  • CAS No:
  • Mol. F.:

Methotrexate Impurity – K

  • CAS No: 532-63-8
  • Mol. F.: C12H14N2O5

Methotrexate Impurity – G

  • CAS No: 2519848-42-9
  • Mol. F.: C28H29N9O6

Methotrexate Impurity – H

  • CAS No: 67022-39-3
  • Mol. F.: C21H24N8O5

Methotrexate Impurity – I

  • CAS No: 66147-29-3
  • Mol. F.: C21H24N8O5

Methotrexate Impurity – J

  • CAS No: 34378-65-9
  • Mol. F.: C22H26N8O5

Methotrexate Impurity – L

  • CAS No: 52980-68-4
  • Mol. F.: C13H16N2O5
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